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There is a close relationship between IR/diabetes and MAFLD, the mechanisms by which IR promotes MAFLD include changes in rates of adipose tissue lipolysis and de novo lipogenesis, impaired mitochondrial fatty acid -oxidation (FAO), changes in fat distribution, and alterations in levels of adipokines and cytokines (Tilg et al., 2017

Additionally, GLP-1 RA use was protective against wet AMD but only when comparing patients taking insulin (HR = .62) and statins (HR = .69)

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