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doi:10.1172/jci.insight.87680 12

However, these findings may not fully reflect the role of endogenous GIP

Notably, studies using glucagon receptordeficient (GCGR - / - ) mouse models have demonstrated that inhibiting glucagon action can ameliorate hyperglycemia even in the absence of insulin ( 5.2 Emerging roles in lipid and bile acid metabolism Beyond glycemic regulation, glucagon plays a multifaceted role in lipid and bile acid metabolism