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Author contributions SHN: Conceptualization, Data curation, Formal Analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Validation, Visualization, Writingoriginal draft

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It has been reported that suppression of O-GlcNAcylation increases basal autophagy flux and enhances the clearance of toxic protein aggregates by improving autophagosome-lysosome function, thereby protecting against huntingtin aggregation and cytotoxicity mediated by mutant HTT (mHTT) in neuroblastoma cells and Drosophila models [156]

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