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Structure-activity relationship studies: The fatty acid conjugation and non-coded residue modifications in retatrutide's structure may be relevant to SAR research investigating how structural modifications affect receptor selectivity and half-life in synthetic peptide compounds

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Analysis of the mice' bone marrow cells, precursors of the monocytes, showed upregulation of proinflammatory cathepsin protein family (CatB and CatZ), which was later terminated during bone marrow differentiation to the macrophages

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