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The use of compounded drugs in patients using GLP-1s without medical supervision pose significant risk and can result in significant consequences, said Marina Basina, MD, a clinical professor in endocrinology, gerontology and metabolism

Pramlintide significantly reduced total energy intake at the buffet meal in both diabetic and obese subjects, with earlier onset of satiety and reduced meal duration

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Given the fact that SGLT2i and GLP1RA safely reduce HbA1c without increased risk of hypoglycemia or weight gain and have beneficial cardiorenal effects across a broad range of subjects with T2DM, we believe these agents should be considered regardless of the presence of CVD