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The rationale for combination use stems from the different tissue concentrations each route achieves

33 NACs clinical benefits may stem from multiple mechanisms besides GSH replenishment, including ( i ) indirect antioxidant effects, ( ii ) provision of hydrogen sulfide (H 2 S) and sulfane sulfur with anti-inflammatory properties, 14,19,37,38 or ( iii ) an impact on NO regulation

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This panel measures key biomarkers of oxidative injury, including 8-OHdG, lipid peroxides, and dityrosine , that reflect the ongoing oxidative burden