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MACE4: cardiovascular death, fatal or non-fatal myocardial infarction, fatal or non-fatal stroke, hospitalized unstable angina

Notably, although gallbladder disorders frequently manifest, advanced gastrointestinal complications such as intestinal obstruction and periprocedural aspiration, and emergent concerns regarding suicidality and ocular problems require further longitudinal studies to refine the usage guidelines for GLP-1 RAs in susceptible populations

The American Diabetes Association (ADA) and Kidney Disease: Improving Global Outcomes (KDIGO) recommend integrating albuminuria assessment into routine care to enhance early detection, refine therapeutic decisions and improve prediction of long-term renal and cardiovascular outcomes [43,44,45]

Endocrinology and Metabolism, 34 (3), 247

The Ethical Questions GLP-1 drugs represent a genuine medical breakthrough for many people struggling with obesity and metabolic disease