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626 In phase 2a, randomized, dose-finding, proof-of-concept study, NRD.E1 induced a clinically relevant pain reduction and was well tolerated

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The glycerol-3-phopshate is generated through the action of glycerol-3-phosphate dehydrogenase acting on the glycolytic intermediate, glyceraldehyde-3-phosphate

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Research suggests morning administration on an empty stomach maximizes absorption for most patients, though circadian glutathione metabolism and genetic factors influence individual response significantly

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