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36 Consistent with previous trials with liraglutide and other GLP-1 receptor agonists, slight increases in resting pulse and lipase activity were observed, 37, 38, 39 the clinical relevance of which remains to be determined

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Successfully weaning off tirzepatide without gaining weight requires strategic planning, including potential dose tapering under medical supervision, intensified lifestyle modifications, and realistic expectations about the biological challenges of weight maintenance

ECL1 and ECL3 were more dynamic in the GLP-1-bound receptor than the TT-OAD2-bound structure