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instead, they may trigger stronger nausea, vomiting, or other gastrointestinal symptoms

GLP-1 receptor agonists like semaglutide and tirzepatide typically should be paused 3-7 days before major surgery to minimize gastric complications and reduce aspiration risk during anesthesia

The final approved dosing, if and when retatrutide receives FDA approval, will be determined by the regulatory review process and may differ from the trial protocols