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This publication represented the first peer-reviewed multi-dose human clinical data for retatrutide and established the pharmacological groundwork for the phase 2 program

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Diarrhea rates increase with dose: 16% at 4 mg, 22% at 8 mg, and 33-34% at 12 mg

symptoms during the preceding 0.5-mg treatment period were not systematically collected in this study and were, therefore, not available for formal comparison