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Multimodal therapeutic approaches, integrating techniques such as chemotherapy, photodynamic therapy, gene delivery, radiotherapy, and immunotherapy, are essential for GBM management, enabling synergistic effects, targeted drug release, and enhanced penetration across the bloodbrain barrier, with MSNs facilitating precise co-delivery of therapeutic agents, stimuli-responsive activation, and real-time monitoring to optimize treatment efficacy and overcome tumor heterogeneity

Molloy, in Reference Module in Biomedical Sciences, 2014 available online at sciencedirect.com/topics/bi

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