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The average AP firing frequency was increased by Ex-4 (from 3.70.8 to 4.20.8 Hz, n =21), but this increase was not statistically significant ( P =0.282, paired t test) (Supplemental Fig

Effects of withdrawal from repeated phencyclidine administration on behavioural function and brain arginine metabolism in rats

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The peptide's activation of ERK1/2 and downstream transcription factors including Egr-1 drives expression of collagen synthesis genes while its enhancement of cellular migration ensures efficient fibroblast recruitment to sites requiring matrix deposition, creating optimal conditions for rapid yet organized tissue reconstruction