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Ethics approval and consent to participate statement All methods were performed in accordance with the relevant guidelines and regulations and all procedures involving animal research were approved by the Animal Care and Use Committee of the University of Western Ontario (Protocol number: 2022-119)

PMID: 34464955 Brennan, R., et al

The method of synthesis according to claim 1, characterized in that: the base used in the coupling reaction in the step (2) is organic base or inorganic base, and the organic base is any one of triethylamine, N-diisopropylethylamine, pyridine, piperidine and aniline

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