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In malignant peripheral nerve sheath tumors, these inactivations of PRC2 components significantly co-occurred with somatic alterations of CDKN2A (81% of all MPNST) and NF1 (72% of non-NF1-associated MPNST)

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The most frequent cause of SLOCA is multiple system atrophy, a rapidly progressive neurodegenerative condition that combines cerebellar ataxia, dysautonomia (typically genitourinary impairment or orthostatic hypotension) and parkinsonism