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Using fibroblasts induced to senesce by ionizing radiation, we further observed that p53 is phosphorylated on Serine 46 and that removing FOXO4 could trigger a clean cell death response, known as apoptosis (de Keizer&Campisi, Cancer Res (2011) 71 (18_Supplement): C35.)

Those are the same individuals who might scar from a biopsy or small acne blemish, or those who have a history of keloid scarring

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But the expectation going in should be calibrated to what the evidence actually supports: modest, localized fat loss that likely requires a supportive diet and exercise foundation to be meaningful

Half of the medium was changed every 3 days after cell adhesion