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A reasonable explanation would be an environmental, viral, nutritional deficiency, and oxidative stress on genetically susceptible patients [7]

The ALDH1A1 gene is located on chromosome 9q21.13 and is composed of 13 exons that encode a 501 amino acid protein

Small molecules such as carbohydrates, amino acids, and hormones pass across the BBB using endothelial carrier-mediated transporters (Oldendorf, 1971), while macromolecules such as transferrin and insulin use endothelial receptor-mediated transport (Banks, 2012)