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Many of these patients were found to have small intestinal bacterial overgrowth (SIBO), which accounts for symptoms such as malabsorption, abdominal distension, and flatulence [132]

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These data demonstrate that high OxPhos signalling is associated with 5FU resistance and suggest that enhanced mitochondrial metabolism promotes treatment failure clinically

An increased gut-bacterial population has positive functional consequences, such as ensuring adequate digestion and preventing constipation, diarrhea, and inflammatory bowel disease (IBD) (84, 85)

GLP-1 (Glucagon-Like Peptide-1) medications are a class of treatments that mimic the natural GLP-1 hormone in the body