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The intramuscular acidic saline injection model is another commonly used model that uses repeated injections of acidic saline into the gastrocnemius muscle to develop widespread pain 34,35

Emerging agents like the retatrutide peptide (a triple agonist targeting GLP-1, GIP, and Glucagon) and orforglipron peptide (an oral non-peptide GLP-1 agonist) are pushing the boundaries of what is possible in pharmacological weight loss, giving providers more options to tailor treatments to individual patient profiles

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None gave lasting relief

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