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Rrf2 Rrf2 repressors are dimers consisting of an N-terminal DNA-binding winged helical domain composed of five helices and two -strands, and a C-terminal helical dimerization domain dominated by a long helix, and thus superficially resemble MerR-family activators (Section 3.2.3)

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When to Reassess If injection-site reactions worsen instead of improving over the first week, if fatigue persists past the loading phase, or if any unusual symptom appears, pause the protocol and consult a qualified clinician