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More specifically, it is important whether the cerebellar motor syndrome and cognitive affective syndrome (syndromes are complexes of symptoms that may have diverse etiologies, i.e., are not diseases sui generis ) result from the same neuropathologies in the mouse model and human patients, including potential secondary brain changes and the pattern of neuropathological development and whether there are analogous mechanisms of links between the neuropathologies and functional impairments (unfortunately not completely known particularly for the CCAS)

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10.1124/jpet.118.247841 J