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Studies using polymeric systems such as PLGA-PEG nanoparticles have demonstrated strong BBB penetration with Angiopep-2 functionalization

Other symptoms observed in patients include increased microvascular density, disturbed GABAergic mechanisms [81], loss of TJs, IgG leakage in hippocampal resections [82], a short period of amnesia [83], sudden anxiety, discomfort, attack of abnormal rage, jerks, shock movements and difficulty in breathing [84]

10.1371/journal.pgen.0030130 10 LiL.LuX.DeanJ

May Influence Pain and Stress Response Pathways Some studies suggest DSIP may interact with pathways involved in pain perception and stress response, making it relevant in neurobiological research focused on central nervous system adaptability and resilience