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The peaks corresponding to these retention times were collected separately using the semi-preparative HPLC method described above and yielded 1 mg each of 6-PA and 6-GA, with purities of ~ 45.5% and ~ 81.7%, respectively (Figure S1)

DOI: 10.1111/j.1745-7262.2008.00417.x 108

A novel, potent, and selective insulin-like growth factor-I receptor kinase inhibitor blocks insulin-like growth factor-I receptor signaling in vitro and inhibits insulin-like growth factor-I receptor dependent tumor growth in vivo

In the SURMOUNT-1 trial, participants taking the highest dose of tirzepatide (15 mg weekly) lost an average of 22.5% of their body weight over 72 weeks