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Certain genetic variations affect glutathione metabolism

Both in vitro and ex vivo studies have shown that Th1 cells exhibit greater susceptibility to AICD than Th2 cells, a difference largely attributed to more efficient Fas ligand surface expression in Th1 cells, which in turn contributes to the Th2-biased immune profile observed in AD (Oberg et al., 1997

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The ADA Standards of Care 2024 acknowledge oxidative stress as a mechanistic contributor to diabetic complications but stop short of recommending specific antioxidant supplementation due to inconsistent clinical outcomes data

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