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The clinical picture that kisspeptin targets best: Women with PMOS who are anovulatory Women who have not responded to standard ovulation induction (clomiphene, letrozole) Women in whom the central hormonal disruption not just insulin resistance is the dominant feature This is not a standalone treatment

Morley JE, Argiles JM, Evans WJ, Bhasin S, Cella D, Deutz NE, Doehner W, Fearon KC, Ferrucci L, Hellerstein MK, Kalantar-Zadeh K, Lochs H, MacDonald N, Mulligan K, Muscaritoli M, Ponikowski P, Posthauer ME, Rossi FF, Schambelan M, Schols AM, Schuster MW, Anker SD

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The criteria come straight from the CMS prior authorization rules

Sartono, E., Kruize, Y