So if you're on a vegan or vegetarian diet where you're not eating foods from animals, you're at risk for B12 deficiency
Additionally, the NNMT substrate nicotinamide 12 is metabolized by the microbiome 56,57 , and thus NNMTi may modulate substrate availability, potentially influencing microbial metabolic capacity to drive the NNMTi-mediated weight loss
Because B12 plays a crucial role in energy production, correcting a deficiency can reduce fatigue and indirectly support weight loss by helping people feel more active
It's not that they are not trying hard enough, or trying in the right direction
Chemotherapy with drugs like 5-fluorouracil has also been associated with acute thiamine deficiency by disrupting thiamine activation, so oncology patients receiving such therapy might receive parenteral thiamine supplementation as part of this B-Complex if needed