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Individuals with GH resistance, as seen in Laron syndrome, a rare genetic condition resulting from an inactivating mutation in the GHR, are protected from cancer and diabetes

NICE guidelines recommend evidence-based weight management through dietary modification (600 kcal/day deficit), 150300 minutes weekly moderate-intensity physical activity, and behavioural change strategies

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Most women at Perfect B continue beyond 12 weeks on a maintenance protocol, which is lower in frequency and sustains the gains made during the initial phase

Once approved, coverage will likely follow the same rules as Wegovy requiring BMI criteria, documentation, and prior authorization