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Maternal high-fat diet and early life stress differentially modulate spine density and dendritic morphology in the medial prefrontal cortex of juvenile and adult rats

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The Phase 2 oral readout showed up to 12% mean body weight reduction after 13 weeks

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PMID: 9849822 Reported Bone-growth effects (preclinical) Longitudinal bone-growth rate increase without IGF-1 elevation (15-day rat study) Johansen and colleagues (Growth Horm IGF Res 1999) reported that adult female rats dosed with ipamorelin for 15 days showed a dose-dependent increase in longitudinal bone-growth rate (from 42 m/day in controls to 4452 m/day) with concurrent body-weight gain