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Abstract Background: Chronic obstructive pulmonary disease (COPD) is a common respiratory disorder manifested as chronic airway inflammation and persistent airflow limitation with the essential mechanism as inflammatory response and oxidative stress induced by toxic exposures such as cigarette smoke (CS)

Additionally, peptides should be kept in tightly sealed containers for example vials to protect them from moisture and air exposure, which can compromise their quality

Furthermore, triptans require careful monitoring because they are known to interact with a large number of other commonly used medications (Bajwa 2012)

Subcutaneous administration delivers the peptide directly into the interstitial space, where it can access the lymphatic system and enter circulation with minimal degradation