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C1q/TNF-related protein 5 upregulates 12/15-LOX through STAT6 signaling to accelerate the development of atherosclerosis, while inhibition of 12/15-LOX reduces LDL oxidation and improves atherosclerosis

Therefore, targeting IGFs may help solve the problem of tumor drug resistance

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In research settings, this extended engagement is associated with prolonged intracellular activation compared to native IGF-1