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Semaglutide has been studied across the SUSTAIN and STEP trial programmes, establishing robust evidence in both type 2 diabetes and obesity without diabetes populations

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Therefore, the combined use of GLP-1 RAs with therapies targeting intrahepatic pathways, such as thyroid hormone receptor (THR-) agonists, fibroblast growth factor-21 (FGF21) analogues, and peroxisome proliferator-activated receptor (PPAR) agonists, presents a promising approach for MASH treatment

Research indicates that GIP signaling plays a role in lipid metabolism and may help the body partition nutrients more effectively, directing calories toward lean tissue maintenance rather than fat storage

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