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Longer needles increase the risk of injecting into muscle tissue, which can lead to more pain and inconsistent absorption

In addition, this treatment has been associated with clinically relevant weight loss, as participants exhibited a decrease of up to 5 kg over 26 weeks across various treatment backgrounds

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In placebo-controlled trials of oral semaglutide for T2DM, semaglutide 7 and 14 mg resulted in a mean increase in heart rate of 2 to 3 bpm

Importantly, there is no evidence of dangerous rebound effects or acute medical complications from stopping tirzepatide itself, but the loss of therapeutic benefits requires proactive management