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It is important to appreciate, however, that the increased risk relates to a disorder that is relatively uncommon. NAION is rare, affecting up to 10 out of 100,000 people in the general population

ALT, glutamic-pyruvic transaminase

N Engl J Med 355:24272443 Patane G, Piro S, Rabuazzo AM, Anello M, Vigneri R, Purrello F (2000) Metformin restores insulin secretion altered by chronic exposure to free fatty acids or high glucose: a direct metformin effect on pancreatic beta-cells

This fundamental shift explains why many users describe the experience as effortless compared to previous weight loss attempts

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