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carnitine palmitoyltransferase I, CPT I) Acetyl-CoA carboxylase (fatty acid synthesis) HMG-CoA synthase & HMG-CoA reductase (do not mix those up) Traps: Carnitine deficiency or CPT I deficiency Impaired transport of LCFA into mitochondria impaired -oxidation

doi:10.1093/jn/131.9.2556S

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This triple mechanism does not treat a disease endpoint it reprograms the metabolic environment in which obesity, type 2 diabetes, MASH, cardiovascular disease, and multiple chronic conditions emerge and progress