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Our later studies on the Shank3 -/- and Cntnap2 -/- knockout mice, the human SH-SY5Y cell line, and the human induced pluripotent stem cellsderived cortical neurons isolated from patients carrying a SHANK3 mutation confirmed the increased levels of NO and protein SNO [172,173,174,175,176]
Although they primarily target joints, central nervous system, gastrointestinal tract, and multiple systemic organs, respectively, a common hallmark across these diseases is a significant disruption in the balance of T cell subsets, particularly a dynamic imbalance between Th17 cells and Treg cells ( Figure 2 )
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