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Free heme is known to scavenge NO, potentially exacerbating the NO deficiency observed in G6PD-d and leading to vasoconstriction, increased vascular permeability, uptake of LDL, immune cell recruitment, and accelerated oxidation of LDL 60
Neither approach has been validated
If this occurs or other allergic symptoms appear, treatment with acetylcysteine should be discontinued unless it is deemed essential and the allergic symptoms can be otherwise controlled
Nishima N, Tanaka S
Simic, T., Mimic-Oka, J., Ille, K., Savic-Radojevic, A
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