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The Gi subunit engages the receptor core using its amphipathic C-terminal 5 helix, forming polar interactions with CCR8 TM2, 3 and ICL3 and hydrophobic interactions with TM5 and ICL2 (Supplementary Fig

The American Society of Anesthesiologists has provided consensus-based guidance suggesting holding GLP-1 agonists for one week in patients on weekly dosing and for one day in those on daily dosing prior to endoscopic or surgical procedures to reduce aspiration risk [11]

While numerous studies have demonstrated encouraging preclinical outcomes using polyphenols such as curcumin, quercetin, resveratrol, and betulin encapsulated in lipid- or polymer-based nanocarriers, their translational promise remains highly variable

2025;37(5):1060-74.e4