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The feasibility of microglia-neuron transdifferentiation is controversial, but evidence has consistently demonstrated that astrocytes and neurons can be reprogrammed into each other, as astrocytes and neurons are closely related and derived from the neuroectodermal lineage, both originating from radial glia

This difference in ischemia type plays a role in the varied effects of drugs in the aforementioned studies

DHL conducted most of the in vivo experiments and acquired and analyzed data