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In biochemical and cellular research systems, ipamorelin acts as an agonist at the ghrelin/growth hormone secretagogue receptor (GHSR-1a) expressed on pituitary somatotroph cells

Furthermore, OHB promotes an anti-inflammatory response in microglial cells by increasing the expression of cytokine Interleukin-10 and decreasing levels of the pro-inflammatory cytokine Interleukin-17, leading to a shift toward the M2 anti-inflammatory phenotype (Polito et al

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This blocks proinflammatory cytokines from binding to their receptors and consequently inhibits transcription of neurotrophins

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