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[9] A separate small multicenter Phase II trial (registered as NCT01393132) in patients with severe dry eye reported significant improvements in both signs and symptoms versus vehicle control

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These proinflammatory changes were shown to increase the binding of fluorescently-labeled leukocytes to the GPx1-deficient endothelial cells compared to the wildtype cells [85]

For patients with diabetes, regular monitoring of blood glucose levels and periodic measurement of hemoglobin A1c helps assess glycemic control and guide dose adjustments