Various human studies have observed an association of a decrease in lung function with higher incidences of deficiency and insufficiency in circulating levels of 25(OH)VD and that of alpha-1-antitrypsin [101,102]
12 Although these compounds are beneficial in the free form, it was also confirmed that when bound to lens proteins, as occurs with increasing age in the lens nucleus, these UV filters become stronger photosensitizers which can, in the presence of oxygen and UV radiation, generate singlet oxygen, superoxide anion, and hydrogen peroxide within the lens nucleus 24 Hydrogen peroxide, although producing little direct damage, can be converted into highly reactive and damaging species in the presence of transition metals
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It is produced from specific nutrients: amino acids that form its structure (cysteine, glutamine & glycine), vitamins, and minerals that participate in complementary reactions during its synthesis process (vitamins B2, magnesium and selenium)
