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[PubMed] 25182544 Lewis LM, Graffeo C, Crosley P, Klausner HA, Clark CL, Frank A, Miner J, Iarrobino R, Chyung Y

Similarly, in a diabetic neuropathy mouse model, topiramate administration (10 or 30 mg/kg) led to a significant, dose-dependent reduction in spinal cord levels of TNF- and IL-1 (Attia et al., 2023)

In comparison to what is known about Source # 1 melatonin regulation, information about the control of extrapineal/mitochondrial melatonin (Source # 2) production is negligible