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Their benefits come with a complex and often under appreciated constellation of adverse effects, some of which are expected, some emerging, and some still poorly understood. Conclusion: GLP-1 RAs exemplify a fundamental principle in contemporary medicine: with every advantage comes a potential drawback

Funduscopy revealed optic disc edema with the presence of small splinter hemorrhages

Lack of knowledge leads to suboptimal transformations

This paper is cited extensively across subsequent reviews including Paschou 2025 and Ridha 2024 as the underlying primary evidence for the proposed cellular mechanism

In addition, nutritional stress caused by a high fat high carbohydrate diet promotes oxidative stress, as evident by increased lipid peroxidation products, a diminished antioxidant system and decreased glutathione levels [82,83]