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If you rely on the medication alone, you may lose weight, but keeping it off long-term will be much harder

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This medication has an unparalleled safety profile

Importantly, subclinical hypothyroidism can represent an adaptive, obesity-related metabolic response, and weight loss itself is known to improve inflammatory and immune profiles

Stress, poor sleep, hormonal fluctuations, and certain foods (especially refined carbohydrates and high-fat meals) can trigger cravings that momentarily override semaglutide's suppressive effect