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Most people with moderate to severe high blood pressure will still need their blood pressure medications along with GLP-1 treatment
Next-generation agents include CagriSema (semaglutide + cagrilintide, NDA filed December 2025, showing 22.7% weight loss), retatrutide (triple GIP/GLP-1/glucagon agonist, 28.7% weight loss in Phase 3), and orforglipron (oral non-peptide GLP-1, submitted to FDA)
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Obes reviews: an Off J Int Assoc Study Obes
However, further characterization of the molecular targets within the interconnected AD and PD pathways is still required
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