Microglia and astrocytes in the CNS are activated to release inflammatory factors and damage neurons, and in the peripheral immune system, alterations in blood immune cell subsets and function, and elevated inflammatory factors correlate with central inflammatory and neurodegenerative changes, but the consistency is influenced by clinical phenotype and disease stage [160, 161]
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However, they refer to different underlying issues
Overall CAD was obtained from a large consortium, CARDIoGRAMplusC4D (42,096 cases, 99,121 controls) [24], as well as the UK Biobank (47,413 cases, 344,551 controls) and Finngen Biobank (21,012 cases, 197,780 controls)
The most plausible explanations link semaglutides effects on the gut and on neural reflexes
