what is retatrutide for How Does Work? Doctor Explains Why It's So Effective Retatrutide: Evidence, Safety & Options

Rossetti L, Hu M

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Retatrutide TRIUMPH-1 (2023) and TRIUMPH-2 (2024) TRIUMPH-1 (Jastreboff et al., NEJM 2023): 338 non-diabetic adults with obesity, 48 weeks at escalating doses: 12 mg dose: 24.2% weight loss 8 mg dose: 22.8% 4 mg dose: 17.5% Placebo: 2.1% TRIUMPH-2 (Rosenstock et al., Lancet 2024) confirmed effects in T2D patients with concurrent NAFLD improvement (hepatic fat reduction 54% at 24 weeks, 12 mg dose)

doi: 10.1038/mp.2015.29 229 BroderickGFuiteJKreitzAVernonSDKlimasNFletcherMA

Next, the samples were ground in 15 mL of a chloroformmethanol mixture and centrifuged at 8,000 g for 15 min