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a minimum of 6 months continuous eligibility pre-index, defined as evidence of any prescription activity in the pre-index period (including index date)

However, long-term use of levodopa often leads to side effects, including fluctuations in motor movements characterized by on and off periods, where the effectiveness of levodopa reported to vary throughout the day

For renewals, the form asks for documented objective evidence of continued benefit (example: decreased HbA1c), but submissions often answer renewal questions as if they were initial requests or fail to provide/confirm objective benefit

Burisch J, Munkholm P

J., Koju, N