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Additionally, most ferroptosis modulators (e.g., ferrostatin-1 and triptolide) are evaluated in preclinical models of early AKI, but their efficacy in patients with established CKD (e.g., with tubulointerstitial fibrosis) is untestedwhether inhibiting ferroptosis can reverse or halt existing fibrosis, or only delay progression from AKI, remains unclear

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The 5-LOX enzyme, found in CD163 + tumor-associated macrophages, promotes the formation of hepatocellular carcinoma (HCC) by generating leukotrienes that augment cancer cell proliferation and stem cell capabilities [275]

(3) Researchers have investigated whether NNMT inhibition might represent a novel approach to modulating energy expenditure and metabolic health

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