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Inhibition of ASAH2 led to increased p53 protein stability, upregulation of Hmox1 expression, suppression of ROS generation, and MDSC death via iron-dependent lipid peroxidation

514 Targeting translation and epigenetic regulation Transcriptional and translational studies have provided a scientific foundation for the discovery of drug targets for underlying mechanisms, such as PI3K/mTOR pathways

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